1. C15:0 Is the Strongest Fatty Acid Predictor of Protected Long-Term Metabolic Health

What researchers found:*

✔ C15:0 ranked #1 out of 27 fatty acids for protecting metabolic health

✔ Every 0.1% increase in C15:0 was associated with a 32% improvement in protected metabolic health

✔ Findings were assigned the highest Confidence of Evidence category among all fatty acids in this study

2. C15:0 Is Associated with Healthy Insulin Sensitivity & Beta Cell Function

What researchers found:*

✔ C15:0 supported insulin sensitivity over a 9-year follow-up

✔ C15:0 supports healthy fasting glucose levels

✔ C15:0 supports healthy overall glucose tolerance on testing

3. C15:0 Activates AMPK & AKT - Key Pathways for Glucose Control

What researchers found:*

✔ C15:0 activates AMPK and AKT pathways for glucose control

✔ C15:0 directly supports glucose uptake and insulin sensitivity in muscle cells

✔ C15:0 supported healthy glucose levels in a preclinical model within 12 weeks

4. Higher C15:0 Levels Are Consistently Associated With Better Metabolic Health Across 16 Cohorts & 12

What researchers found:*

✔ C15:0 met the Bradford Hill Criteria for protecting metabolic health

✔ Consistent associated protective effect across 16 cohorts and 12 countries

✔ C15:0 received the highest metabolic health protection score compared to EPA, DHA, and other nutrients studied.

5. Every 0.1% Increase in C15:0 Is Associated With Measurably Better Metabolic Protection

What researchers found:*

✔ Higher C15:0 levels were associated with greater metabolic health protection

✔ Every 0.1% increase in C15:0 was associated with a 32% improvement in metabolic health, up to 0.6%

✔ Each 100 mg of pure C15:0 supplementation increased circulating C15:0 levels by approximately 0.1% in clinical trials

6. Multiple Large Population Studies Continue to Show the Same Result: Higher C15:0, Better Long-Term Metabolic Health

What researchers found:*

✔ Higher C15:0 linked to better long-term metabolic health across 112,193+ participants

✔ Consistent findings across the U.S., Europe, Asia, and Australia

✔ Declining C15:0 levels tracked alongside worsening global metabolic health

Why People Are Paying Attention

The consistency of findings - across 16 cohorts, 12 countries, and more than a decade of prospective research - backs C15:0 as a nutrient that supports long-term metabolic health.*