1. C15:0 Supports Healthy Liver Function

In both clinical trials and preclinical studies, raised C15:0 supported healthy liver function, including lower AST and ALT — two commonly measured markers tied to liver health.

Researchers have also linked higher C15:0 to less liver fat in people and preclinical models.

What researchers found:*

✔ Supported healthy liver function

✔ Lower AST and ALT

✔ Less liver fat

2. C15:0 Supports Healthy Cholesterol & Triglyceride Levels

Recent findings showed that C15:0 protected against increases in triglycerides and total cholesterol associated with a high fat diet.†

Researchers also observed higher HDL cholesterol levels in C15:0 groups.

Separately, higher C15:0 has been associated with lower total and LDL cholesterol in humans.

What researchers found:*

✔ Lower triglycerides

✔ Lower total cholesterol

✔ Higher HDL cholesterol

3. C15:0 Helps Lower Oxidative Stress & Proinflammatory Activity In The Liver

Recent research showed that C15:0 supported multiple antioxidant activities in the face of a high fat diet.†

Researchers also found that C15:0 lowered key proinflammatory cytokines tied to liver function, including TNFα and IL-6.

The study noted that elevated oxidative stress and proinflammatory activity can negatively affect liver function over time.

What researchers found:*

✔ Lowered oxidative stress in the liver

✔ Lowered TNFα and IL-6

✔ Supported liver health in the face of a high fat diet

4. C15:0 Increases AMPK Activation Associated With Metabolic & Liver Health

Researchers found that C15:0 significantly increased AMPK activation — a pathway involved in helping the body maintain healthy glucose control and insulin levels.†

Additional findings showed that C15:0 lowered SREBP-1, a pathway tied to fat and cholesterol production in the liver, while also increasing PPARɑ gene activity, which is associated with fatty acid metabolism and liver health.†

Together, these findings help explain how C15:0 supported metabolic and liver health in the study.

What researchers found:*

✔ Increased AMPK activation

✔ Lowered SREBP-1

✔ Increased PPARɑ gene activity

5. Multiple Studies Continue Showing Liver Protective Effects Associated With C15:0

Multiple studies have found that people with higher circulating levels of C15:0 had healthier long-term metabolic and liver health markers.

Researchers have also observed improved liver function in randomized controlled clinical trials with C15:0 supplementation.

What researchers found:*

✔ Higher C15:0 levels associated with healthier metabolic markers

✔ Higher C15:0 levels associated with healthier liver markers

✔ Improved liver function reported in clinical trials

Why people are paying attention:

The consistency of findings across studies continues to build interest in C15:0 research, including how it can support liver health.